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Article

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief.

Expert opinion on therapeutic targets - 1 Aug 2016

Emery Edward C, Luiz Ana Paula, Wood John N

Abstract excerpt

INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects. AREAS COVERED: Sodium channel subtypes have been linked to human pain syndromes through genetic studies. Gain of function mutations in Nav1.7, 1.8 and 1.9 can cause pain, whilst loss of function Nav1.7 mutations lead to loss of pain...

Topics

Analgesics
Analgesics, Opioid
Animals
Chronic Pain
Drug Design
Humans
Mice
Mice, Knockout
Molecular Targeted Therapy
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Naloxone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sodium Channel Blockers

Source

Open in PubMed Open full text

Identifiers

PMID: 26941184
DOI: 10.1517/14728222.2016.1162295
PMCID: PMC4950419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26941184-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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