Article

Analgesia linked to Nav1.7 loss of function requires μ and δ opioid receptors

2018-04-09

Abstract excerpt

Functional deletion of the SCN9A gene encoding sodium channel Nav1.7 makes humans and mice pain-free (1,2). Opioid signaling contributes to this analgesic state (3). Here we show that the pharmacological block or deletion of both μ and δ opioid receptors is required to abolish Nav1.7 null opioid-related analgesia.κ-opioid receptor antagonists were without effect. Enkephalins encoded by the Penk gene are upregula...

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Literature Corpus work: 17f78a4f-38af-5999-8e3e-e3aec98f5c23
DOI: 10.1101/297184

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