Article

The mechanism of analgesia in Na <sub>V</sub> 1.7 null mutants

2020-06-02

Abstract excerpt

<h4>Summary</h4> Deletion of SCN9A encoding the voltage-gated sodium channel Na V 1.7 in humans leads to profound pain insensitivity and anosmia. Conditional deletion of Na V 1.7 in sensory neurons of mice also abolishes pain suggesting the locus of analgesia is the nociceptor. Here we demonstrate that Na V 1.7 knockout mice have essentially normal nociceptor activity using in vivo calcium imaging and extrac...

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Literature Corpus work: 20395e45-298a-5b52-820e-e03e4d752fed
DOI: 10.1101/2020.06.01.127183

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