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Article

There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study.

Journal of the American Heart Association - 6 Aug 2024

Zhong Aifang, Tan Yejun, Liu Yaqiong, Chai Xiangping, Peng Weijun

Abstract excerpt

BACKGROUND: The association between poor cardiovascular health and cognitive decline as well as dementia progression has been inconsistent across studies. This study used Mendelian randomization (MR) to investigate the causal relationship between Alzheimer disease (AD), circulating levels of total-tau, and coronary artery disease (CAD). METHODS AND RESULTS: This study used MR to investigate the causal...

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Identifiers

PMID: 39082403
DOI: 10.1161/JAHA.123.032814
PMCID: PMC11964012

Genes

CAD

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