Article
The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026
Lai Yongjie, Her Qoua L, Zhang Yue, Xu Hong, Kucharska-Newton Anna, Ji Dongze, Wu Guorong, Garden Gwenn, Stürmer Til, Wang Tiansheng, Xu Yang
Abstract excerpt
INTRODUCTION: Given the complexity of dementia, the inconsistent evidence on statins and dementia highlights the need for robust methods to assess heterogeneous treatment effects (HTEs). METHODS: We emulated a target trial using UK Biobank comparing statin initiators and non-initiators aged ≥55 years. Marginal structural models were fitted to estimate 5-year adjusted risk difference (aRD). We used iterative...
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