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Causal relationship between cholesterol-lowering therapy and Alzheimer Disease: evidence from genetic correlation and Mendelian randomization study

2023-04-24

Abstract excerpt

The objective of this study was to investigate the causal relationship between cholesterol-lowering therapy and Alzheimer's disease (AD) using Mendelian Randomization (MR) with two sets of genetic instruments derived from UK Biobank, GLGC, and GWAS ATLAS. Instrumental variables were selected based on SNPs that were significantly associated with lipid-lowering drugs or targets, but not with outcome or confounding f...

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Literature Corpus work
9d598a19-16d9-575e-84d6-284d032bbe8e
DOI
10.21203/rs.3.rs-2822676/v1
Open publication

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Causal relationship between cholesterol-lowering therapy and Alzheimer Disease: evidence from genetic correlation and Mendelian randomization studyDOI 10.21203/rs.3.rs-2822676/v1
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