Article

CREB and CREM reciprocally regulate expression of ST2 in Tregs and mediate the balance between type 1 and type 2 immune responses

2024-08-29

Abstract excerpt

Background: Regulatory T cells (T regs ) are gatekeepers of immune homeostasis and characterized by expression of Foxp3, which maintains T reg identity. The cAMP response element binding protein CREB is suggested to regulate T reg function and expression, however detailed analysis of CREB function in Tregs is lacking. <h4>Methods:</h4> Mice with a Foxp3-specific knockout of CREB were generated, phenotypically c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fee0210d-b00a-5bef-9046-63a88d81c1f8
DOI: 10.22541/au.172489829.93821221/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CREB and CREM reciprocally regulate expression of ST2 in Tregs and mediate the balance between type 1 and type 2 immune responsesDOI 10.22541/au.172489829.93821221/v1Read

The cAMP response element modulator (CREM) regulates TH2 mediated inflammationSemantic proximity Read

CREB/CRTC2-Induced GPR65 Orchestrates Th17 Metabolic Fitness and Pathogenic Effector FunctionSemantic proximity Read

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody productionSemantic proximity Read

REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREMSemantic proximity Read

Epigenetic Regulation of the IL-13-induced Human Eotaxin-3 Gene by CREB-binding Protein-mediated Histone 3 AcetylationSemantic proximity Read

Loss of TET proteins in regulatory T cells unleashes effector functionSemantic proximity Read

Ferritin heavy chain supports stability and function of the regulatory T cell lineageSemantic proximity Read

ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathwaySemantic proximity Read

Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic responseSemantic proximity Read

CCAR2 Dictates tTreg Instability and iTreg-Driven Dendritic Cell Tolerance via Divergent AKT/mTOR Modulation in High-Salt MicroenvironmentsSemantic proximity Read

Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3Semantic proximity Read

Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma.Semantic proximity Read