Article
Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma.
Respirology (Carlton, Vic.) - 1 Mar 2009
Matsumoto Koichiro, Inoue Hiromasa, Fukuyama Satoru, Kan-O Keiko, Eguchi-Tsuda Miyuki, Matsumoto Takafumi, Moriwaki Atsushi, Nakano Takako, Nakanishi Yoichi
Abstract excerpt
BACKGROUND AND OBJECTIVE: A forkhead/winged-helix family transcriptional repressor, Foxp3, is highly expressed on CD4(+)CD25(+) T regulatory cells. The role of Foxp3(+)CD4(+)CD25(+) T regulatory cells in asthma remains to be elucidated. Using mouse models and peripheral blood mononuclear cells (PBMC) from subjects with allergic asthma, we aimed to explore whether Foxp3(+)CD4(+)CD25(+) T regulatory cells associate...
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