Article

TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells

2025-07-04

Abstract excerpt

<h4>Summary</h4> TMC1 and TMC2, the pore-forming subunits of the mechanoelectrical transduction (MET) complex in inner ear sensory hair cells, are essential for auditory and vestibular function. Pathogenic mutations in TMC1 are a leading cause of genetic hearing loss, but their underlying cellular mechanisms remain poorly understood. Here, we reveal that TMC1 and TMC2 are cholesterol-regulated lipid scramblases w...

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Literature Corpus work: fed77900-e68d-5d8c-987b-e0b5ecdb764f
DOI: 10.1101/2025.07.03.663083

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