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Article

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study.

Journal of translational medicine - 20 Jul 2024

Guo Xinyu, Jin Wenyan, Wen Yuchen, Wang Zhiqin, Ren Xiaotong, Liu Zhaoyun, Fu Rong, Cai Zhigang, Li Lijuan

Abstract excerpt

BACKGROUND: Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or thrombocytopenia. MDS exhibits considerable heterogeneity in prognosis, with approximately 30% of patients progressing to acute myeloid leukemia (AML). Single cell RNA-sequencing (scRNA-seq) is a new and powerful technique to profile disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39033303
DOI: 10.1186/s12967-024-05496-x
PMCID: PMC11265062

Genes

HMGA1
CD34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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