Article

USP8 Status Affects the Immune Landscape of Corticotroph Pituitary Adenomas

2021-04-08

Abstract excerpt

<title>Abstract</title> <p>Purpose Activating somatic mutations in ubiquitin-specific protease-8 (<italic>USP8</italic>), encoding a deubiquitinating protein, are found in approximately 30% of corticotroph-derived pituitary adenomas (CPA). <italic>USP8</italic> has immunomodulating properties that were demonstrated in non-tumoral diseases. Our study aims to assess the influence of USP8 mutation status on the imm...

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Literature Corpus work: feadafe2-428b-5a54-8a21-83822e0892da
DOI: 10.21203/rs.3.rs-372059/v1

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