Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson's tumor.

doi:10.1530/EJE-17-0634

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Article

Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson's tumor.

European journal of endocrinology - 1 Jan 2018

Pérez-Rivas Luis G, Theodoropoulou Marily, Puar Troy H, Fazel Julia, Stieg Mareike R, Ferraù Francesco, Assié Guillaume, Gadelha Monica R, Deutschbein Timo, Fragoso Maria C, Kusters Benno, Saeger Wolfgang, Honegger Jürgen, Buchfelder Michael, Korbonits Márta, Bertherat Jérôme, Stalla Günter K, Hermus Ad R, Beuschlein Felix, Reincke Martin

Abstract excerpt

OBJECTIVE: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene are frequent in corticotroph tumors causing Cushing's disease (CD). Corticotroph tumor progression, the so-called Nelson's syndrome (NS), is a potentially life-threatening complication of bilateral adrenalectomy in patients with refractory CD that is caused by the development of an ACTH-secreting tumor of the pituitary gland. Whether...

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PMID: 28982703
DOI: 10.1530/EJE-17-0634

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USP8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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