Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pangenomic Classification of Pituitary Neuroendocrine Tumors.

Cancer cell - 13 Jan 2020

Neou Mario, Villa Chiara, Armignacco Roberta, Jouinot Anne, Raffin-Sanson Marie-Laure, Septier Amandine, Letourneur Franck, Diry Ségolène, Diedisheim Marc, Izac Brigitte, Gaspar Cassandra, Perlemoine Karine, Verjus Victoria, Bernier Michèle, Boulin Anne, Emile Jean-François, Bertagna Xavier, Jaffrezic Florence, Laloe Denis, Baussart Bertrand, Bertherat Jérôme, Gaillard Stephan, Assié Guillaume

Abstract excerpt

Pituitary neuroendocrine tumors (PitNETs) are common, with five main histological subtypes: lactotroph, somatotroph, and thyrotroph (POU1F1/PIT1 lineage); corticotroph (TBX19/TPIT lineage); and gonadotroph (NR5A1/SF1 lineage). We report a comprehensive pangenomic classification of PitNETs. PitNETs from POU1F1/PIT1 lineage showed an epigenetic signature of diffuse DNA hypomethylation, with transposable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to Epigenome

Share to Neuroendocrine Tumors

Share to Pituitary Gland

Share to Pituitary Neoplasms

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 31883967
DOI: 10.1016/j.ccell.2019.11.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pangenomic Classification of Pituitary Neuroendocrine Tumors.PMID 31883967Read ↗

Transcription Factor–Based Classification of Pituitary Neuroendocrine Tumors: Practical Immunohistochemical Algorithms, Molecular Correlates, and Diagnostic Challenges in the 5th WHO EraSemantic proximity Read ↗

DNA methylation profiling of pituitary neuroendocrine tumors identifies distinct clinical and pathological subtypes based on epigenetic differentiationSemantic proximity Read ↗

Annotation of pituitary neuroendocrine tumors with genome-wide expression analysisSemantic proximity Read ↗

A review of multiomics platforms in pituitary adenoma pathogenesisSemantic proximity Read ↗

Splicing diversity enhances the molecular classification of pituitary neuroendocrine tumorsSemantic proximity Read ↗

Single-cell transcriptome and genome analyses of pituitary neuroendocrine tumorsSemantic proximity Read ↗

A clinicopathological study of non-functioning pituitary neuroendocrine tumours using the World Health Organization 2022 classificationSemantic proximity Read ↗

Whole Genome Sequencing and single-cell transcriptomics identify<i>KMT2D</i>as a potential new driver for pituitary adenomasSemantic proximity Read ↗

Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor CellsSemantic proximity Read ↗

Clinical integration and application of the 2022 WHO pituitary tumor classificationSemantic proximity Read ↗

Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional ContinuumSemantic proximity Read ↗

Transcriptome and methylome analysis reveals three cellular origins of pituitary tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.