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Article

Somatic USP8 alteration affects the immune landscape of corticotroph pituitary adenomas- a pilot study.

Hormones (Athens, Greece) - 1 Dec 2024

Greidinger Dahlia, Halperin Reut, Zemet Roni, Maixner Nitzan, Tirosh Amit

Abstract excerpt

INTRODUCTION: Somatic mutations in ubiquitin-specific protease-8 (USP8), encoding a deubiquinating protein, are found in approximately 30% of corticotroph-derived pituitary adenomas (CPAs). Stratifin, a protein encoded by SFN, inhibits USP8 catalytic activity. USP8 has immunomodulating properties that have been demonstrated in non-tumoral diseases. METHODS: We assessed the influence of USP8 on the immune...

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PMID: 38819743
DOI: 10.1007/s42000-024-00569-4

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