Article

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

2024-08-20

Abstract excerpt

Epigenetic dysregulation is widespread in cancer. However, the specific epigenetic regulators and the processes they control to drive cancer phenotypes are poorly understood. Here, we employed a novel, scalable and high-throughput in vivo method to perform iterative functional screens of over 250 epigenetic regulatory genes within autochthonous oncogenic KRAS-driven lung tumors. We identified multiple novel epige...

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Literature Corpus work: fe8631f1-05f6-5e7b-a564-c01f13ae2b26
DOI: 10.1101/2024.08.19.607671

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