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Article

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition.

BMC genomics - 8 Dec 2014

Lin Steven H, Wang Jing, Saintigny Pierre, Wu Chia-Chin, Giri Uma, Zhang Jing, Menju Toshi, Diao Lixia, Byers Lauren, Weinstein John N, Coombes Kevin R, Girard Luc, Komaki Ritsuko, Wistuba Ignacio I, Date Hiroshi, Minna John D, Heymach John V

Abstract excerpt

BACKGROUND: DNA methylation is associated with aberrant gene expression in cancer, and has been shown to correlate with therapeutic response and disease prognosis in some types of cancer. We sought to investigate the biological significance of DNA methylation in lung cancer. RESULTS: We integrated the gene expression profiles and data of gene promoter methylation for a large panel of non-small cell lung cancer...

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Identifiers

PMID: 25486910
DOI: 10.1186/1471-2164-15-1079
PMCID: PMC4298954

Genes

EGFR
AXL
SPINT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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