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Article

Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response.

British journal of cancer - 1 Aug 2024

Nagelberg Amy L, Sihota Tianna S, Chuang Yu-Chi, Shi Rocky, Chow Justine L M, English John, MacAulay Calum, Lam Stephen, Lam Wan L, Lockwood William W

Abstract excerpt

BACKGROUND: Identification of driver mutations and development of targeted therapies has considerably improved outcomes for lung cancer patients. However, significant limitations remain with the lack of identified drivers in a large subset of patients. Here, we aimed to assess the genomic landscape of lung adenocarcinomas (LUADs) from individuals without a history of tobacco use to reveal new genetic drivers of...

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Share to Adenocarcinoma of Lung
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Exome Sequencing

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Genomics

Share to Lung Neoplasms

Source

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Identifiers

PMID: 38890444
DOI: 10.1038/s41416-024-02755-y
PMCID: PMC11300780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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