Article

ATR function is indispensable to allow proper mammalian follicle development

2018-11-16

Abstract excerpt

Mammalian female fertility relies on the proper development of follicles. Right after birth in mouse, oocytes associate with somatic ovarian cells to form follicles. These follicles grow during adult lifetime to produce viable gametes. In this study, we analyzed the role of the ATM and rad3-related (ATR) kinase in mouse oogenesis and folliculogenesis using a hypomorphic mutation of the Atr gene (Murga et al., 200...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fe7174d9-fab4-598b-b6a7-dcc147092bf4
DOI: 10.1101/471698

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ATR function is indispensable to allow proper mammalian follicle developmentDOI 10.1101/471698Read

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase ISemantic proximity Read

The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte agingSemantic proximity Read

The DNA damage response is required for oocyte cyst breakdown and follicle formation in miceSemantic proximity Read

Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.Semantic proximity Read

Not all germ cells are created equal: Aspects of sexual dimorphism in mammalian meiosisSemantic proximity Read

CHFR is important for the survival of male premeiotic germ cells.Semantic proximity Read

Oocytes Progress beyond Prophase in the Presence of DNA DamageSemantic proximity Read

Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female miceSemantic proximity Read

Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptorsSemantic proximity Read

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.Semantic proximity Read

Regulation of meiotic entry and gonadal sex differentiation in the human: normal and disrupted signalingSemantic proximity Read

Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in miceSemantic proximity Read