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Article

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I

15 Oct 1998

Abstract excerpt

Infertility is a common feature of the human disorder ataxia-telangiectasia and Atm-deficient mice are completely infertile. To gain further insight into the role of ATM in meiosis, we examined meiotic cells in Atm-deficient mice during development. Spermatocyte degeneration begins between postnatal days 8 and 16.5, soon after entry into prophase I of meiosis, while oocytes degenerate late in embryogenesis prior...

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Identifiers

PMID: 9735362
DOI: 10.1242/dev.125.20.4007

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