Article

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain

2026-02-16

Abstract excerpt

<h4>ABSTRACT</h4> Antibodies and other protein therapeutics have revolutionized medicine, but their application is largely limited to extracellular targets. The lack of efficient intracellular delivery methods remains a major bottleneck. Here, we engineered a family of small (∼90 amino acids), metabolically stable membrane translocation domains (MTDs) by modifying the loop sequences of a human fibronectin type II...

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Literature Corpus work: 19a92f0f-a39d-54b1-937e-580067b5de40
DOI: 10.64898/2026.02.13.705776

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