Article

NN-800s: Brain-penetrant trimeric nanobodies enable potent TNFα inhibition via TfR1-mediated transcytosis

2026-04-30

Abstract excerpt

Tumor necrosis factor alpha (TNFα) is a central mediator of neuroinflammation and synaptic dysfunction in multiple central nervous system (CNS) disorders, including Alzheimer’s disease. Although clinically approved TNFα inhibitors are highly effective in peripheral inflammatory diseases, their therapeutic application in CNS disorders is severely limited by poor blood–brain barrier (BBB) penetration. Here, we repor...

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Literature Corpus work: 96c3c3de-e68e-5bf3-867b-f40968f14c3b
DOI: 10.64898/2026.04.28.721316

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