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A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice

2024-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Preclinical and clinical studies show that mild to moderate hypothermia is neuroprotective in sudden cardiac arrest, ischemic stroke, perinatal hypoxia/ischemia, traumatic brain injury and seizures. Induction of hypothermia largely involves physical cooling therapies, which induce several clinical complications, while some molecules have shown to be efficient in pharmacologically induced hypothe...

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Literature Corpus work
90a2aff5-7eeb-5e25-9da3-1d07d160d77b
DOI
10.1101/2024.07.15.603208
Open publication

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