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Novel VHH targeting a unique TfR1 epitope for efficient cross-species delivery of drugs in the CNS

2025-05-23

Abstract excerpt

The blood-brain barrier (BBB) is a major obstacle for delivering therapeutic agents to the central nervous system (CNS), posing significant challenges for treating neurological disorders. Among current strategies to improve brain drug exposure, hijacking physiological pathways involved in receptor-mediated transcytosis (RMT) has emerged as a promising strategy. While targeting transferrin receptor 1 (TfR1) is wide...

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Identifiers and source

Literature Corpus work
31b69cbe-a15e-5702-b678-52612322b47d
DOI
10.1101/2025.05.23.649291
Open publication

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