Article
Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion
2019-05-05
Abstract excerpt
Macrophages drive atherosclerotic plaque progression and rupture, hence attenuating their atherosclerosis-inducing properties holds promise for reducing coronary heart disease (CHD). Recent studies in mouse models have demonstrated that Tribbles 1 (Trib1) regulates macrophage phenotype and shows that Trib1 deficiency increases plasma cholesterol and triglyceride levels, suggesting that reduced TRIB1 expression m...
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Identifiers and source
- Literature Corpus work
- fe3e9f08-12a8-5e5b-8af5-ae10abbb9c83
- DOI
- 10.1101/615872