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Article

Tribbles pseudokinases in cardiovascular diseases: Molecular mechanisms, genetic insights, and therapeutic prospects.

Pharmacological research - 1 May 2026

Zhang Wenkang, Zhang Minhao, Sha Ziqi, Yan Gaoliang, Tang Chengchun, Li Mingkang

Abstract excerpt

Cardiovascular disease (CVD) represents a significant global public health challenge, with its high incidence and mortality rates imposing a substantial socioeconomic burden. Tribbles family proteins (TRIB1, TRIB2, and TRIB3), functioning as pseudokinases, play a pivotal role in the pathogenesis and progression of various CVDs, including coronary heart disease, heart failure, hypertension, cardiomyopathy, and...

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Calcium-Calmodulin-Dependent Protein Kinases
Cardiovascular Diseases
Cell Cycle Proteins
Genetic Predisposition to Disease
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Repressor Proteins

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Identifiers

PMID: 41864376
DOI: 10.1016/j.phrs.2026.108168

Genes

TRIB1
TRIB2
TRIB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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