Article

Endoplasmic Reticulum Stress Impairs Macrophage Efferocytosis via TRIB3-Rab27a Signaling and Exacerbates Atherosclerotic Plaque Necrosis

2025-01-24

Abstract excerpt

<title>Abstract</title> <p>Defective clearance of apoptotic cells (efferocytosis) by macrophages is a key driver of atherosclerotic plaque necrosis which is associated with adverse clinical outcomes such as myocardial infarction and stroke. The mechanistic basis of defective efferocytosis in atherosclerotic plaque macrophages is not well understood. We show that hyperlipidemia and the consequent accumulation of l...

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Literature Corpus work: d28ffb08-777a-58ef-9a1c-ce08a3b2c89b
DOI: 10.21203/rs.3.rs-4616005/v1

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