Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease.

Journal of the American Heart Association - 3 Jun 2014

Douvris Adrianna, Soubeyrand Sébastien, Naing Thet, Martinuk Amy, Nikpay Majid, Williams Andrew, Buick Julie, Yauk Carole, McPherson Ruth

Abstract excerpt

BACKGROUND: The TRIB1 locus has been linked to hepatic triglyceride metabolism in mice and to plasma triglycerides and coronary artery disease in humans. The lipid-associated single nucleotide polymorphisms (SNPs), identified by genome-wide association studies, are located ≈30 kb downstream from TRIB1, suggesting complex regulatory effects on genes or pathways relevant to hepatic triglyceride metabolism. The goal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Artery Disease
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatocytes

Share to Intracellular Signaling Peptides and Proteins

Share to Lipid Metabolism

Share to Real-Time Polymerase Chain Reaction

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 24895164
DOI: 10.1161/JAHA.114.000884
PMCID: PMC4309087

Genes

TRIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease.PMID 24895164Read ↗

Trouble With Tribbles-1Semantic proximity Read ↗

The role of TRIB1 in lipid metabolism; from genetics to pathways.Semantic proximity Read ↗

Tribbles-1: a novel regulator of hepatic lipid metabolism in humansSemantic proximity Read ↗

The A>T polymorphism of the tribbles homolog 1 gene is associated with serum triglyceride concentrations in Japanese community-dwelling women.Semantic proximity Read ↗

Effect of TRIB1 Variant on Lipid Profile and Coronary Artery Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in miceSemantic proximity Read ↗

TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.Semantic proximity Read ↗

Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population.Semantic proximity Read ↗

TRIB1 and TRPS1 Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid ConcentrationsSemantic proximity Read ↗

Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in MiceSemantic proximity Read ↗

The long non-coding RNA<i>TRIB1AL</i>links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespanSemantic proximity Read ↗

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.