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Functional Characterization of LcpA, a Surface-Exposed Protein of<i>Leptospira</i>spp. That Binds the Human Complement Regulator C4BP

20 Apr 2010

Abstract excerpt

We have previously shown that pathogenic leptospiral strains are able to bind C4b binding protein (C4BP). Surface-bound C4BP retains its cofactor activity, indicating that acquisition of this complement regulator may contribute to leptospiral serum resistance. In the present study, the abilities of seven recombinant putative leptospiral outer membrane proteins to interact with C4BP were evaluated. The protein...

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PMID: 20404075
DOI: 10.1128/iai.00279-10

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