Article

Separating the genetics of disease, treatment and treatment response using graphical modeling and large-scale electronic health records

2025-04-30

Abstract excerpt

Genetic variants affect baseline health and biomarker values, which in turn impact both the therapy selected for an individual and the magnitude of change induced by the medication. Here, we propose an approach for complex longitudinal repeated measures biobank data, which separates genetic effects for disease from the genetic effects for medication usage and those for treatment response. For 211,845 individuals,...

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Literature Corpus work: fe30dc8e-5c8a-561f-badc-f7dba809be57
DOI: 10.1101/2025.04.29.25326633

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