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Article

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks.

Nature communications - 13 Jan 2021

Amar David, Sinnott-Armstrong Nasa, Ashley Euan A, Rivas Manuel A

Abstract excerpt

Causal inference via Mendelian randomization requires making strong assumptions about horizontal pleiotropy, where genetic instruments are connected to the outcome not only through the exposure. Here, we present causal Graphical Analysis Using Genetics (cGAUGE), a pipeline that overcomes these limitations using instrument filters with provable properties. This is achievable by identifying conditional...

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Identifiers

PMID: 33441555
DOI: 10.1038/s41467-020-20516-2
PMCID: PMC7806647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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