Article

Improving Genetic Association Studies with a Novel Methodology that Unveils the Hidden Complexity of All-Cause Heart Failure

2023-08-04

Abstract excerpt

<h4>Motivation</h4> Genome-Wide Association Studies (GWAS) commonly assume phenotypic and genetic homogeneity that is not present in complex conditions. We designed Transformative Regression Analysis of Combined Effects (TRACE), a GWAS methodology that better accounts for clinical phenotype heterogeneity and identifies gene-by-environment (GxE) interactions. We demonstrated with UK Biobank (UKB) data that TRACE in...

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Literature Corpus work: c70305d3-6e1b-53d8-86bf-dc025724de27
DOI: 10.1101/2023.08.02.23293567

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