Article
The Electronic Medical Records and Genomics study: Design and analytic framework for assessing the impact of genome-informed risk assessments.
American journal of human genetics - 2 Apr 2026
Limdi Nita, Beasley T Mark, Cortopassi Josh, Davis Brittney, Bangash Hana, Chen Jingheng, Chisholm Rex L, Chung Wendy K, Cimino James J, Connolly John, Crosslin David R, Davis Kyle W, DiVietro Alanna, Esplin Edward D, Freimuth Bob, Gordon Adam, Hakonarson Hakon, Hamed Marwan, He Megan, Hoell Christin, Holm Ingrid, Hripscak George, Irvin Margurite R, Jarvik Gail P, Karavite Dean, Karlson Elizabeth W, Kenny Eimear E, Khan Atlas, Kiryluk Krzysztof, Knerr Sarah, Korf Bruce, Kottyan Leah, Kullo Iftikhar, Larkin Katie, Lennon Niall, Linder Jodell E, Manolio Teri, Martin Lisa J, McNally Elizabeth M, Morse Jennifer, Murphy Shawn, Namjou Bahram, Odgis Jacqueline A, Orlando Lori, Pacheco Jennifer, Peterson Josh F, Pineda-Alvarez Daniel E, Prows Cindy, Puckelwartz Megan, Purcell Jasmine, Rasmussen-Torvik Laura, Rehm Heidi, Roden Dan M, Rosenthal Elisabeth A, Rowley Robb, Sabatello Maya, Schaid Daniel, Sharp Richard, Smith Johanna L, Smoller Jordan W, Soper Emily R, Sterling Rene, Suckiel Sabrina A, Terek Shannon, Thayer Jeritt, Ting Yi-Lee, Tiwari Hemant, Velez-Edwards Digna, Wagholikar Kavishwar B, Walunas Theresa, Wei Wei-Qi, Weng Chunua, Wiesner Georgia, Abul-Husn Noura S, Veenstra David L
Abstract excerpt
The Electronic Medical Records and Genomics (eMERGE) Network developed and implemented a genome-informed risk assessment (GIRA) to communicate genomic (polygenic risk scores [PRSs], integrated risk scores [IRSs], and monogenic results), clinical, and family history-based risk for 11 chronic diseases and provide recommended healthcare recommendations. GIRA reports have now been returned to 23,840 participants and...
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