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DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma

11 Dec 2024

Abstract excerpt

BACKGROUND: Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies suggest a survival advantage for gcGB patients, the underlying causes remain elusive. GcGBs are associated with TP53 mutations, and gcs were shown to accumulate DNA double-strand...

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PMID: 39663543
DOI: 10.1186/s13148-024-01793-w

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