Article
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016
Gujar Amit D, Le Son, Mao Diane D, Dadey David Y A, Turski Alice, Sasaki Yo, Aum Diane, Luo Jingqin, Dahiya Sonika, Yuan Liya, Rich Keith M, Milbrandt Jeffrey, Hallahan Dennis E, Yano Hiroko, Tran David D, Kim Albert H
Abstract excerpt
Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD+). Nevertheless, how the regulation of this metabolic cofactor interfaces with signal transduction networks remains poorly understood in glioblastoma. Here, we report nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting step in NAD+ synthesis, is highly expressed...
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