Article

The kinetics of bedaquiline diffusion in tuberculous cavities opens a window for emergence of resistance

2024-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Cavitary tuberculosis (TB) is difficult to cure and a site of relapse. Bedaquiline has been a wonder drug in the treatment of multidrug resistant TB, but emergence of resistance threatens its sustained success. To investigate the role of drug distribution in resistance development, we designed a novel laser-capture microdissection scheme to spatially resolve the penetration of bedaquiline in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d3bd68e-2f9c-5e7b-874e-e45517eb3bb0
DOI: 10.1101/2024.10.09.617456

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The kinetics of bedaquiline diffusion in tuberculous cavities opens a window for emergence of resistanceDOI 10.1101/2024.10.09.617456Read

Lesion penetration predicts tuberculosis regimen success: a validated translational tool for de-risking late-stage drug developmentSemantic proximity Read

<scp>TB</scp> drug development: immunology at the tableSemantic proximity Read

Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapiesSemantic proximity Read

Innovative Strategies for Combating Multidrug-Resistant Tuberculosis: Advances in Drug Delivery Systems and TreatmentSemantic proximity Read

Establishing a framework for human dose prediction in anti-tuberculosis drug developmentSemantic proximity Read

Protocol for a phase 2, partially-blinded, randomised trial assessing the safety and efficacy of sorfequiline or bedaquiline, in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis (NC-009)Semantic proximity Read

Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis.Semantic proximity Read

Structural and functional analysis of the <i>Mycobacterium tuberculosis</i> MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistanceSemantic proximity Read

Population pharmacokinetics and dose evaluations of linezolid in the treatment of multidrug-resistant tuberculosisSemantic proximity Read

Three-dimensional in vivo monitoring of mycobacterial infections and therapeutic efficacy based on tissue-clearing technology CUBICSemantic proximity Read

Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First StepsSemantic proximity Read

Optimization and clinical validation of dual-target RT-LAMP for SARS-CoV-2Semantic proximity Read