Article

Systematic measurement of combination drug landscapes to predict <i>in vivo</i> treatment outcomes for tuberculosis

2021-02-04

Abstract excerpt

A lengthy multidrug chemotherapy is required to achieve a durable cure in tuberculosis. Variation in Mycobacterium tuberculosis drug response is created by the differing microenvironments in lesions, which generate different bacterial drug susceptibilities. To better realize the potential of combination therapy to shorten treatment duration, multidrug therapy design should deliberately explore the vast combinatio...

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Literature Corpus work: 0543f194-99af-566f-a7b5-26d0cfe80de8
DOI: 10.1101/2021.02.03.429579

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