Article

Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic Competence

2017-06-25

Abstract excerpt

Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessary for tumorigenesis. Here, we investigate the contribution of enhancer elements to the metastatic phenotype of osteosarcoma. Through epigenomic profiling, we identify substantial differences in enhancer activity between primary and metastatic tumors in human patients as well as nearisogenic pairs of high and low lu...

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Literature Corpus work: fe0e4805-89ce-5864-8392-01f474e87802
DOI: 10.1101/155416

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