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Article

Genetic and clonal dissection of osteosarcoma progression and lung metastasis.

International journal of cancer - 1 Sept 2018

Xu Huaiyuan, Zhu Xiaojun, Bao Hua, Wh Shek Tony, Huang Zongwen, Wang Yongqian, Wu Xue, Wu Yong, Chang Zhili, Wu Shuyu, Tang Qinglian, Zhang Huizhong, Han Anjia, Mc Cheung Kenneth, Zou Changye, Yau Raymond, Ho Wai-Yip, Huang Gang, Batalha Sellma, Lu Jinchang, Song Guohui, Kang Yao, Shao Yang W, Lam Ying Lee, Shen Jingnan, Wang Jin

Abstract excerpt

Osteosarcoma is a primary malignant bone tumor that has a high potential to metastasize to lungs. Little is known about the mechanisms underlying the dissemination of OS cancer cells to lungs. We performed whole exome sequencing of 13 OS primary tumors, with matched lung metastases and normal tissues. Phylogenetic analyses revealed that lung metastatic tumors often harbor clones that are nonexistent or rare in...

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Identifiers

PMID: 29569716
DOI: 10.1002/ijc.31389

Genes

KEAP1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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