Article

Novel mutations in the RECQL4 gene affect its helicase functions, interactions with the BLM helicase and chemotherapeutics-induced cell death

2025-01-15

Abstract excerpt

<title>Abstract</title> <p> RecQ family of DNA helicases play pivotal roles in DNA replication, repair and responses to DNA damage or replication stress. Several human RecQ helicases are defective in diseases associated with chromosomal instability, premature aging and cancer. We recently discovered novel mutations in the <italic>RECQL4</italic> gene in glioblastoma (GBM), the most malignant brain tumour in ad...

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Literature Corpus work: fe033741-2ca7-55dc-9eb8-73dde71fe746
DOI: 10.21203/rs.3.rs-5826981/v1

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