Article
RECQL4 helicase has oncogenic potential in sporadic breast cancers.
The Journal of pathology - 1 Mar 2016
Arora Arvind, Agarwal Devika, Abdel-Fatah Tarek Ma, Lu Huiming, Croteau Deborah L, Moseley Paul, Aleskandarany Mohammed A, Green Andrew R, Ball Graham, Rakha Emad A, Chan Stephen Yt, Ellis Ian O, Wang Lisa L, Zhao Yongliang, Balajee Adayabalam S, Bohr Vilhelm A, Madhusudan Srinivasan
Abstract excerpt
RECQL4 helicase is a molecular motor that unwinds DNA, a process essential during DNA replication and DNA repair. Germ-line mutations in RECQL4 cause type II Rothmund-Thomson syndrome (RTS), characterized by a premature ageing phenotype and cancer predisposition. RECQL4 is widely considered to be a tumour suppressor, although its role in human breast cancer is largely unknown. As the RECQL4 gene is localized to...
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