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RecQ Helicase Somatic Alterations in Cancer

15 Jun 2022

Abstract excerpt

Named the “caretakers” of the genome, RecQ helicases function in several pathways to maintain genomic stability and repair DNA. This highly conserved family of enzymes consist of five different proteins in humans: RECQL1, BLM, WRN, RECQL4, and RECQL5. Biallelic germline mutations inBLM,WRN, andRECQL4have been linked to rare cancer-predisposing syndromes. Emerging research has also implicated somatic alterations...

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PMID: 35782872
DOI: 10.3389/fmolb.2022.887758

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