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Article

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

1 Jan 2012

Abstract excerpt

Mutations in RECQL4 helicase are associated with Rothmund-Thomson syndrome (RTS). A subset of RTS patients is predisposed to cancer and is sensitive to DNA damaging agents. The enhanced sensitivity of cells from RTS patients correlates with the accumulation of transcriptionally active nuclear p53. We found that in untreated normal human cells these two nuclear proteins, p53 and RECQL4, instead colocalize in the...

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PMID: 22357944
DOI: 10.1242/jcs.101501

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RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stressPMID 22357944Read ↗

RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.Semantic proximity Read ↗

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stabilitySemantic proximity Read ↗

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.Semantic proximity Read ↗

The involvement of human RECQL4 in DNA double‐strand break repairSemantic proximity Read ↗

Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.Semantic proximity Read ↗

The versatile RECQL4.Semantic proximity Read ↗

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replicationSemantic proximity Read ↗

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication.Semantic proximity Read ↗

Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.Semantic proximity Read ↗

Functional characterisation of a RECQL4 mutation in Rothmund-Thomson syndromeSemantic proximity Read ↗

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.Semantic proximity Read ↗

Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.Semantic proximity Read ↗

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