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Deciphering SPP1-related macrophage signaling in the pathogenesis of intervertebral disc degeneration

18 Jan 2025

Abstract excerpt

This study delved into the molecular mechanisms underlying mechanical stress-induced intervertebral disc degeneration (msi-IDD) through single-cell and high-throughput transcriptome sequencing in mouse models and patient samples. Results exhibited an upsurge in macrophage presence in msi-IDD intervertebral disc (IVD) tissues, with secreted phosphoprotein 1 (SPP1) identified as a pivotal driver exacerbating...

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PMID: 39825191
DOI: 10.1007/s10565-024-09948-4

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