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Single nuclear‐spatial transcriptomic sequencing reveals distinct puncture‐induced cell subpopulations in the intervertebral disc of a rat model

1 Jun 2025

Abstract excerpt

Abstract Objective We aim to investigate the spatiotemporal dynamics of intervertebral disc (IVD) cell subpopulations in IVD degeneration (IVDD). Methods To gain combined spatial and transcriptomic insights into IVDD, we employed both spatial transcriptomic sequencing (stRNA‐seq) and single nucleus RNA sequencing (snRNA‐seq) in a rat puncture‐induced IVDD model. The findings were verified in rat and human IVD by...

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PMID: 40515444
DOI: 10.1002/ctm2.70370

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