Article

SARS-CoV-2 variants exhibit increased kinetic stability of open spike conformations as an evolutionary strategy

2021-10-12

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 variants of concern harbor mutations in the Spike (S) glycoprotein that confer more efficient transmission and dampen the efficacy of COVID-19 vaccines and antibody therapies. S mediates virus entry and is the primary target for antibody responses. Structural studies of soluble S variants have revealed an increased propensity towards conformations accessible to receptor human Angioten...

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Literature Corpus work: fdf03d39-aa8c-5bee-864a-36c5d523411e
DOI: 10.1101/2021.10.11.463956

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