Article

Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

2021-11-01

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Structural and dynamic data have shown that S can adopt multiple conformations, which controls the exposure of the ACE2-binding site in the RBD. Here, using single-molecule Förster...

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Literature Corpus work: 2edc9b27-4337-5bbb-97cf-ed1d35899790
DOI: 10.1101/2021.10.29.466470

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