Spike Protein Mutation-Induced Changes in the Kinetic and Thermodynamic Behavior of Its Receptor Binding Domains Explain Their Higher Propensity to Attain Open States in SARS-CoV-2 Variants of Concern

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Spike (S) protein opening in SARS-CoV-2 controls the accessibility of its receptor binding domains (RBDs) to host receptors and immune recognition. Along the evolution of SARS-CoV-2 to its variants of concern (VOC)─alpha, beta, gamma, delta, and omicron─their S proteins showed a higher propensity to attain open states. Deciphering how mutations in S protein can...

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