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Article

Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants

1 Jan 2025

Abstract excerpt

The SARS-CoV-2 spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor to mediate viral entry, with mutations in different variants influencing binding affinity and conformational dynamics. Using large-scale molecular dynamics simulations, we analyzed the Spike-ACE2 complex in the wild-type (WT), Beta, and Delta variants. Our findings reveal significant conformational rearrangements at the...

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PMID: 40778313
DOI: 10.1016/j.csbj.2025.07.034

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