Article

Allosteric Cross-Talk Among SARS-CoV-2 Spike’s Receptor-Binding Domain Mutations Triggers an Effective Hijacking of Human Cell Receptor

2021-04-30

Abstract excerpt

<h4>ABSTRACT</h4> The rapid and relentless emergence of novel highly transmissible SARS-CoV-2 variants, possibly decreasing vaccine efficacy, currently represents a formidable medical and societal challenge. These variants frequently hold mutations on the Spike protein’s Receptor-Binding Domain (RBD), which, binding to the Angiotensin-Converting Enzyme 2 (ACE2) receptor, mediates viral entry into the host cells....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5bcd9d91-8d0b-58ad-b3bc-d82d0de60b05
DOI: 10.1101/2021.04.30.441093

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allosteric Cross-Talk Among SARS-CoV-2 Spike’s Receptor-Binding Domain Mutations Triggers an Effective Hijacking of Human Cell ReceptorDOI 10.1101/2021.04.30.441093Read

Allosteric Cross-Talk among Spike's Receptor-Binding Domain Mutations of the SARS-CoV-2 South African Variant Triggers an Effective Hijacking of Human Cell Receptor.Semantic proximity Read

Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging VariantsSemantic proximity Read

Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an escape mutantSemantic proximity Read

Coevolution, Dynamics and Allostery Conspire in Shaping Cooperative Binding and Signal Transmission of the SARS-CoV-2 Spike Protein with Human Angiotensin-Converting Enzyme 2Semantic proximity Read

Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variantsSemantic proximity Read

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atom SimulationsSemantic proximity Read

Structural dynamics and allosteric communication of a SARS-like bat coronavirus spike glycoprotein.Semantic proximity Read

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2Semantic proximity Read

Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 VariantsSemantic proximity Read

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineages.Semantic proximity Read

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction.Semantic proximity Read

Mechanistic insights into the effects of key mutations on SARS-CoV-2 RBD-ACE2 binding.Semantic proximity Read