Article

cDC1 and interferons promote spontaneous CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell protective responses to breast cancer

2020-12-24

Abstract excerpt

Here we show that efficient breast cancer immunosurveillance relies on cDC1, conventional CD4 + T cells, CD8 + cytotoxic T lymphocytes (CTL) and later NK/NK T cells. For this process, cDC1 were required constitutively, but especially during the T cell priming phase. In the tumor microenvironment, cDC1 interacted physically and jointly with both CD4 + T cells and tumorspecific CD8 + T cells. We found that inter...

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Identifiers and source

Literature Corpus work: fde19592-405a-5dd7-b304-1c6cd11697f0
DOI: 10.1101/2020.12.23.424092

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